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Quotes - Engineering - SalesCIP/SIP Heat Exchangers for Pharmaceutical & Biotech
Every bioreactor, buffer tank, purification skid, and filling line must achieve validated sterility and zero pyrogen levels. Our ASME-BPE, electropolished CIP/SIP heat exchangers deliver precise WFI heating, pure steam generation, and complete clean/sterilize-in-place — eliminating endotoxins, bioburden, and cross-contamination while meeting the strictest cGMP, FDA, EMA, and Annex 1 requirements.
Critical Pharmaceutical & Biotech CIP/SIP Applications
- Antibiotic Fluid Sanitization: Validated SIP of fermentation broth lines using pure steam and WFI with double-tubesheet exchangers.
- Aseptic Filling Nozzles: 140°C pure steam sterilization of filling needles and manifolds with fully drainable, zero-dead-leg designs.
- Purified Water Loops: 80–90°C hot WFI circulation for PW/WFI storage and distribution systems with Ra = 15 µin electropolish.
- Tank & Vessel SIP: 121–135°C pure steam delivery for bioreactor, media, and buffer tanks with full condensate drainage.
- Vaccine Production Lines: Complete CIP/SIP of harvest, purification, and formulation skids with validated endotoxin removal.
- Bioburden & Endotoxin Control: Proven removal of pyrogens and microbes with riboflavin, endotoxin, and bioburden validation.
Shell & Tube
CIP/SIP Pharma Exchangers
- Double Tubesheet ASME-BPE
- Pure Steam & WFI Compatible
- Fully Drainable & SIP
Plate & Frame
CIP/SIP Pharma Exchangers
- High Regeneration Efficiency
- Ra = 15 µin Electropolish
- Fast CIP & Validated SIP
The Critical Role of Sanitary CIP/SIP Heat Exchangers in Pharmaceutical & Biotech
Pharmaceutical and biotech facilities operate under zero-tolerance for bioburden, endotoxins, and cross-contamination. Non-compliant or poorly designed heat exchangers become permanent sources of contamination, risking patient safety and batch failure.
Our ASME-BPE exchangers eliminate that risk with electropolished 316L surfaces (Ra = 15 µin), zero dead legs, full drainability, and proven resistance to daily CIP and 135°C pure steam SIP cycles — delivering validated sterility assurance for WFI systems, bioreactors, purification skids, and aseptic filling lines.
A global vaccine manufacturer achieved Annex 1 compliance and zero sterility failures after installing our double-tubesheet pure steam systems. A leading biologics CDMO reduced CIP/SIP time 50% using our high-regeneration plate exchangers for buffer preparation.
With third-party validation, full material traceability, and decades of performance in the world’s most critical pharma/biotech plants, our CIP/SIP heat exchangers are the trusted foundation for safe, compliant, and efficient sterile manufacturing.
