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Quotes - Engineering - SalesCIP/SIP Heat Exchangers for Vaccine Production Equipment Sterilization
Vaccine manufacturing requires absolute sterility across bioreactors, harvest lines, purification skids, and formulation vessels. Our ASME-BPE CIP/SIP heat exchangers deliver pure steam for 135°C SIP, hot WFI circulation, and validated cleaning — eliminating bioburden, endotoxins, and cross-contamination while meeting the strictest cGMP, FDA, EMA, and Annex 1 standards.
Critical Vaccine Production Equipment Sterilization Applications
- Bioreactor SIP: 135°C pure steam sterilization of cell culture and viral production vessels with double-tubesheet exchangers and full condensate drainage.
- Harvest Line Cleaning: Aggressive CIP/SIP of high-protein harvest lines with Ra = 15 µin electropolished exchangers for complete residue removal.
- Purification Skid SIP: Pure steam sterilization of chromatography columns, filters, and hold tanks with validated lethality and zero dead legs.
- Formulation Tank CIP: Hot WFI and caustic circulation for adjuvant and antigen mixing tanks with full endotoxin and bioburden control.
- Multi-Product Changeover: Complete CIP/SIP removes previous vaccine residues for safe switching between mRNA, viral vector, and subunit platforms.
- Endotoxin & Bioburden Validation: Proven removal of pyrogens and microbes with riboflavin, endotoxin, and bioburden testing documentation.
Shell & Tube
CIP/SIP Vaccine Exchangers
- Double Tubesheet ASME-BPE
- Pure Steam Compatible
- Fully Drainable SIP
Plate & Frame
CIP/SIP Vaccine Exchangers
- High Regeneration Efficiency
- Ra = 15 µin Electropolish
- Fast CIP & Validated SIP
The Critical Role of Sanitary CIP/SIP Heat Exchangers in Vaccine Production Equipment Sterilization
Vaccine production equipment — bioreactors, harvest tanks, purification skids, and formulation vessels — demands zero bioburden and endotoxin risk. Non-compliant exchangers become contamination sources, threatening batch integrity and patient safety.
Our ASME-BPE exchangers eliminate that risk with double-tubesheet designs, electropolished surfaces (Ra = 15 µin), full drainability, and proven resistance to 135°C pure steam SIP — delivering validated sterility for multi-platform vaccine manufacturing.
A global mRNA vaccine producer achieved zero sterility failures after installing our pure steam systems. A viral vector facility reduced SIP time 50% with our high-regeneration plate exchangers for WFI circulation.
With third-party validation, full traceability, and decades of performance in vaccine plants worldwide, our CIP/SIP heat exchangers are the trusted standard for safe, compliant vaccine equipment sterilization.
