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Quotes - Engineering - SalesCIP/SIP Heat Exchangers for Purified Water Loop CIP
PW/WFI distribution loops are prone to biofilm and endotoxin buildup if not properly sanitized. Our ASME-BPE CIP/SIP heat exchangers provide continuous 80–90°C hot WFI circulation, pure steam generation, and validated clean-in-place — maintaining microbial and endotoxin control throughout the entire loop from storage tanks to point-of-use.
Critical Purified Water Loop CIP Applications
- Hot WFI Sanitization: Continuous 80–90°C hot WFI circulation for biofilm control in PW/WFI storage and distribution piping.
- Pure Steam Generation: Supplies pure steam for 121–135°C SIP of storage tanks, heat exchangers, and point-of-use valves.
- Loop CIP Validation: Temperature-controlled caustic/acid cycles with riboflavin and endotoxin testing for complete coverage.
- Point-of-Use Sanitization: Hot WFI or pure steam delivery to valves, hoses, and user points with zero dead legs.
- Storage Tank CIP/SIP: Full sanitization of PW/WFI tanks with validated pure steam and hot water cycles.
- Endotoxin & Bioburden Control: Proven removal of pyrogens and microbes with full documentation and validation.
Shell & Tube
CIP/SIP PW Exchangers
- Double Tubesheet ASME-BPE
- Pure Steam & WFI Compatible
- Fully Drainable SIP
Plate & Frame
CIP/SIP PW Exchangers
- High Regeneration Efficiency
- Ra = 15 µin Electropolish
- Fast CIP & Validated SIP
The Critical Role of Sanitary CIP/SIP Heat Exchangers in Purified Water Loop CIP
PW/WFI loops are susceptible to biofilm and endotoxin if not continuously sanitized. Non-compliant exchangers fail to maintain hot temperatures, leading to microbial excursions and batch failures.
Our ASME-BPE exchangers eliminate that risk with electropolished surfaces (Ra = 15 µin), zero dead legs, full drainability, and proven resistance to 90°C hot WFI and pure steam SIP — delivering validated microbial and endotoxin control throughout the loop.
A leading biologics facility achieved zero endotoxin excursions after installing our hot WFI circulation systems. A vaccine producer reduced loop CIP/SIP time 50% using our high-regeneration plate exchangers.
With third-party validation, full traceability, and decades of performance in pharma/biotech plants, our CIP/SIP heat exchangers are the trusted standard for safe, compliant purified water loop management.
